Дрожжевой бета-глюкан

Бета-глюкан дрожжей — это «модификатор биологической реакции».’ за счет усиления активности иммунной системы. Его функция была доказана в различных исследованиях.

Дрожжевой бета-глюкан

Бета-глюкан дрожжей — это «модификатор биологической реакции».’ за счет усиления активности иммунной системы. Его функция была доказана в различных исследованиях.

Поделись фейсбук
Поделись твиттер
Поделись связанный

Как дрожжевой бета-глюкан помогает иммунной системе?



The immune health is crucial for staying healthy. A sound immune system is of great importance to cope with different diseases or illnesses. We all need to enhance our immune system. Regular exercise or taking some natural or artificial product directly or indirectly boosts the immune system.
Natural substances that improve the immune system are the subject of investigation for the last decades. A wide range of synthetic and natural products are available in the market described as having immunomodulatory effects. However, only a few products are probably the best studied, and interesting ones are β-glucans (Goodridge et al., 2009; Stier et al., 2014).

History of β-glucans as immune system modulator

Before identifying β-glucans as an immune modulator, shiitake mushroom (Lentinus edodes) in Japan and Ganoderma luciderm in China were used in traditional medicine, boosting the body immune system. The immune-modulating effect of β-glucan discovered in the last century.
Since more than 6000 publications have published investigating the immune-modulation effect of the β-glucans, such as antimicrobial and anti-inflammatory abilities, the β-glucans show immune-modulating effects on various organisms.
The results on humans and other animals like fish, rodents, invertebrates, and other farm animals are encouraging. Furthermore, other beneficial effects of β-glucans include healing wounds, hepatoprotective, antidiabetic, and cholesterol reduction (Novak & Ветвицкая, 2008).

Importance of β-glucans in immune modulation

Various studies show that β-glucan have the potential to enhance the immune system. The majority of options exist in the market while choosing multiple products to boost the immune system, and β-glucan is one of those products. The β-glucan is water-soluble dietary fiber in the cell wall of yeast, fungi, bacteria, algae, lichens, and plants (barley, oat, seaweed).
However, the β-glucans from different sources have different modulating effects but not all. It depends upon the primary chemical structure of β-glucan. For example, cellulose a (1,4)- β-linked glucan does not have any immune-modulatory effect. While yeast and fungus-derived β-glucan, (1,3)-β-linked with small chains of (1,6)-β-linked side chains are known for their immune-modulating effect.
Besides the primary chemical structure, the immune-modulating effect of β-glucan also depends on its solubility, molecular mass, tertiary structure, polymer charge, branching pattern, solution conformation, and its manufacturing, from isolation to purification affect its immune modulation efficiency (Vannucci et al., 2013).

Various sources of β-glucans

Various β-glucans function in multiple ways based on their sources; for example, cereal-based beta-glucan reduces LDL-cholesterol, healing wounds, skin injury. Still, there is not enough scientific evidence that such kind of β-glucans enhances the immune system.
Mushroom-derived β-glucans are associated with lowering cholesterol levels, improving heart health, wound healing, and in some cases, strengthening the immune system to some extent.

Yeast β-glucan is found abundantly in the cell wall of baker’s yeast (Saccharomyces cerevisiae). The β-glucan is a water-soluble polysaccharide consist of glucose subunits.

The yeast-derived β-glucan, specifically the baker’s yeast Saccharomyces cerevisiae, is well-known for boosting immunity compared to brewer’s yeast. It means not all yeast strain-derived β-glucan are equally efficient. It also helps in the healing of wounds. For immune system modulation, the source from which β-glucan source is essential (Seo et al., 2019).

Mode of action β-glucans in immune system modulation

Interaction between Immune cells and β-glucans

The human gastrointestinal tract is a vital immune organ enriched with dendritic cells and macrophages immune cells. Thus, anything passing through the gastrointestinal tract immune cells recognizes it. These immune cells contain specialized pattern-recognition receptors (PRRs) recognizing and responding to any structure related to harmful microbes.

Adaptive immunity

With the β-glucan ingestion, cell surface immune receptors, PRRs consider it a foreign substance and directly bind. Then, the binding between these two alert the immune cells and induce a series of biochemical reactions, which renders the immune system behave effectively. So, the innate immune system is a complex signaling network of germ-line encoded pattern-recognition receptors (PRRs). The immune cells or other cells usually express to induce various cell signaling pathways. Thus it activates a wide range of signaling pathways. Mainly, it has physiological effects and modulates the immune system. These signaling pathways are related to a group of compounds responsible for physiological effects. Finally, β-glucans help the immune system to react effectively against harmful microorganisms during infection. Thus, β-glucans ensure safety and overall health benefits. Consequently, β-D-glucan triggers innate immune responses and develop adaptive immunity (Murphy et al., 2010; Novak & Ветвицкая, 2008).

Yeast β-glucan is versatile in developing an adaptive immune system.

Initially, the дрожжевой β-глюкан triggered the interleukin-1β-(1L-1β) mediated cell signaling responses primarily through macrophages via dectin-1 signaling. Yeast β-glucan stimulates the effect on macrophages and shows strong immune modulation effects. Additionally, the yeast β-glucan interacts with microfold (M)-cells in the small intestine. Then, the M-cells take β-glucan and transport it to the immune cells present in Peyer’s patches from the intestine lumen. Finally, macrophages take up the yeast β-glucan, and it gets degraded. Eventually, it became available to the circulatory system and distributed systemically. Thus, yeast β-glucan are potential activators of the innate immune system that enhance the functional activity of immune cells. Finally, it activates the network of cell signaling pathways, which systemically develop adaptive immune responses against diseases (Murphy et al., 2010; Novak & Ветвицкая, 2008).

Why choose yeast β-glucans for immune-modulatory effects?

While selecting the best and high-quality β-glucan, which is safe and effective in modulating the immune system, we need to consider some important points. Дрожжевой β-глюкан biological activity, mechanism of action, the chemical structure is well studied, and immune system functioning and supported by research.
Yeast-derived β-glucans prime the immune system to perform efficiently instead of boosting it. It enables the immune system to recognize the foreign pathogen. It recognizes the microbial pathogens and phagocytizes the infective cells and limit the further spread of disease. Yeast-derived β-glucan is equally effective for all ages of people, from children to old age. It is also effective in stress release in athletes and women passing through stress and improves overall physical health (Seo et al., 2019; Stier et al., 2014; Talbott & Тэлботт, 2012).


Goodridge, H. S., Wolf, A. J., & Underhill, D. M. (2009). Beta-glucan recognition by the innate immune system. Immunological Reviews, 230(1), 38–50. https://doi.org/10.1111/j.1600-065X.2009.00793.x
Мерфи, Э.А., Дэвис, Дж.М., & Кармайкл, доктор медицины (2010). Иммуномодулирующее действие β-глюкана. Текущее мнение о клиническом питании и метаболической помощи, 13 (6), 656–661. https://doi.org/10.1097/MCO.0b013e32833f1afb
Новак М., & Ветвицка, В. (2008). β-глюканы, история и современность: иммуномодулирующие аспекты и механизмы действия. Журнал иммунотоксикологии, 5 (1), 47–57. https://doi.org/10.1080/15476910802019045
Со Г., Хён К., Чхве С., Ким Ю.М., & Чо, М. (2019). Ранозаживляющее действие четырех типов бета-глюкана. Прикладная биологическая химия, 62(1), 20. https://doi.org/10.1186/s13765-019-0428-2.
Stier, H., Ebbeskotte, V., & Gruenwald, J. (2014). Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan. Nutrition Journal, 13, 38. https://doi.org/10.1186/1475-2891-13-38
Тэлботт, С.М., & Талботт, Дж. А. (2012). Добавка с бета-глюканами из пекарских дрожжей уменьшает симптомы верхних дыхательных путей и улучшает настроение у женщин, находящихся в состоянии стресса. Журнал Американского колледжа питания, 31 (4), 295–300. https://doi.org/10.1080/07315724.2012.10720441
Ваннуччи Л., Кризан Дж., Сима П., Стахеев Д., Каха Ф., Райсиглова Л., Хорак В., & Saieh, M. (2013). Immunostimulatory properties and antitumor activities of glucans. International Journal of Oncology, 43(2), 357–364. https://doi.org/10.3892/ijo.2013.1974

Поделись фейсбук
Поделись твиттер
Поделись связанный

45 Ответы

  1. I would like to thank you for the efforts you’ve put in writing this site. I am hoping the same high-grade web site post from you in the upcoming as well. In fact your creative writing abilities has inspired me to get my own blog now. Actually the blogging is spreading its wings quickly. Your write up is a good example of it.

  2. Wonderful blog! Do you have any recommendations for aspiring writers? I’m planning to start my own blog soon but I’m a little lost on everything. Would you recommend starting with a free platform like WordPress or go for a paid option? There are so many choices out there that I’m completely overwhelmed .. Any ideas? Thanks a lot!

  3. Hey there! Quick question that’s entirely off topic. Do you know how to make your site mobile friendly? My weblog looks weird when viewing from my iphone 4. I’m trying to find a theme or plugin that might be able to fix this problem. If you have any recommendations, please share. Thanks!

  4. Я часто веду блог и очень ценю ваш контент. Статья на самом деле вызывает у меня интерес. Я собираюсь добавить ваш веб-сайт в закладки и продолжать проверять новую информацию.

  5. One thing I’d really like to touch upon is that weightloss system fast can be achieved by the appropriate diet and exercise. Someone’s size not just affects appearance, but also the complete quality of life. Self-esteem, depressive disorders, health risks, in addition to physical skills are impacted in excess weight. It is possible to do everything right whilst still having a gain. Should this happen, a condition may be the root cause. While a lot of food and not enough physical exercise are usually responsible, common health concerns and widespread prescriptions can certainly greatly help to increase size. Thanks alot : ) for your post here.

  6. Pretty element of content. I just stumbled upon your site and in accession capital to say that I acquire actually loved account your blog posts. Any way I will be subscribing on your feeds or even I success you get right of entry to constantly rapidly.

  7. Attractive section of content. I just stumbled upon your site and in accession capital to assert that I get in fact enjoyed account your blog posts. Anyway I will be subscribing to your augment and even I achievement you access consistently rapidly.

  8. This article is absolutely incredible! The author has done a fantastic job of conveying the information in an captivating and enlightening manner. I can’t thank him enough for sharing such precious insights that have definitely enlightened my awareness in this topic. Bravo to him for crafting such a gem!

  9. It is appropriate time to make a few plans for the future and it’s time to be happy. I have read this post and if I could I wish to counsel you some attention-grabbing things or suggestions. Perhaps you can write subsequent articles regarding this article. I want to learn even more things about it!

  10. Thanks for sharing superb informations. Your site is very cool. I’m impressed by the details that you?ve on this web site. It reveals how nicely you perceive this subject. Bookmarked this web page, will come back for extra articles. You, my friend, ROCK! I found just the information I already searched everywhere and simply couldn’t come across. What a perfect web site.

  11. Hey! I could have sworn I’ve been to this website before but after checking through some of the post I realized it’s new to me. Nonetheless, I’m definitely happy I found it and I’ll be bookmarking and checking back often!

  12. I?m impressed, I must say. Actually not often do I encounter a blog that?s both educative and entertaining, and let me tell you, you may have hit the nail on the head. Your idea is outstanding; the difficulty is one thing that not sufficient individuals are talking intelligently about. I am very blissful that I stumbled throughout this in my seek for one thing regarding this.

  13. Greetings from Los angeles! I’m bored at work so I decided to check out your website on my iphone during lunch break. I love the knowledge you present here and can’t wait to take a look when I get home. I’m surprised at how quick your blog loaded on my cell phone .. I’m not even using WIFI, just 3G .. Anyhow, very good blog!

  14. Поделились отличной информацией .. очень понравилось читать этот пост, спасибо, автор, за то, что поделился этим постом .. ценю

  15. Я думаю, что этот пост имеет смысл и действительно помогает мне, пока я все еще в замешательстве, после прочтения сообщений на этом сайте я понимаю.

оставьте ответ

Ваш электронный адрес не будет опубликован. Обязательные поля помечены *